The self-folding films are novel class of bioinspired materials, which mimic movement mechanisms of plants and are able to spontaneously fold and form complex 3D structures. The self-folding films consist of two polymers with different properties. As a result of its non-equal swelling of polymers, the film bends and forms tubes, capsules or more complex structures. Similar to ORIGAMI, the self-folding films provide unique possibility for straightforward fabrication of complex 3D constructs with cavities as well as with structured inner and outer walls that cannot be that easy achieved using currently available technologies. Self-folding films are particular promising for encapsulation and release of cells as well as for design of porous scaffolds.