TU Dresden


Genomic Gastroenterology - Selected Publications

Thangapandi VR, Knittelfelder O, Brosch M, Patsenker E, Vvedenskaya O, .. Hampe* J, Subramanian P*. (2020). Loss of Hepatic Mboat7 Leads to Liver Fibrosis. Gut. https://doi.org/10.1136/gutjnl-2020-320853

Segovia-Miranda, F., Morales-Navarrete, H., Kücken, M., Moser, V., Seifert, S., Repnik, U., … Hampe, J*, Zerial, M*. (2019). Three dimensional spatially resolved geometrical and functional models of human liver tissue reveal new aspects of NAFLD progression. Nature Medicine, 25(12), 1885–1893. doi.org/10.1038/s41591-019-0660-7


Schafmayer, C., Harrison, J. W., Buch, S., Lange, C., Reichert, M. C., Hofer, P., … Hampe, J. (2019). Genome-wide association analysis of diverticular disease points towards neuromuscular, connective tissue and epithelial pathomechanisms. Gut. doi.org/10.1136/gutjnl-2018-317619


Strnad, P., Buch, S., Hamesch, K., Fischer, J., Rosendahl, J., Schmelz, R., …, Hampe, J*, Trautwein, C*. (2019). Heterozygous carriage of the alpha1-antitrypsin PiZ variant increases the risk to develop liver cirrhosis. Gut. doi.org/10.1136/gutjnl-2018-316228


Brosch, M., Kattler, K., Herrmann, A., von Schönfels, W., Nordström, K., Seehofer, D., … Hampe, J. (2018). Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control. Nature Communications, 9(1), 1–11. doi.org/10.1038/s41467-018-06611-5


Stickel, F., Buch, S., Nischalke, H. D., Weiss, K. H., Gotthardt, D., Fischer, J., … Hampe, J. (2018). Genetic variants in PNPLA3 and TM6SF2 predispose to the development of hepatocellular carcinoma in individuals with alcohol-related cirrhosis. The American Journal of Gastroenterology. doi.org/10.1038/s41395-018-0041-8


Teufel, A., Itzel, T., Erhart, W., Brosch, M., Wang, X. Y., Kim, Y. O., … Hampe, J. (2016). Comparison of Gene Expression Patterns Between Mouse Models of Nonalcoholic Fatty Liver Disease and Liver Tissues From Patients. Gastroenterology. doi.org/10.1053/j.gastro.2016.05.051


Buch, S., Stickel, F., Trépo, E., Way, M., Herrmann, A., Nischalke, H. D., … Hampe, J. (2015). A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis. Nature Genetics, 47(12), 1443–1448. doi.org/10.1038/ng.3417


Horvath, S., Erhart, W., Brosch, M., Ammerpohl, O., Von Schönfels, W., Ahrens, M., … Hampe, J. (2014). Obesity accelerates epigenetic aging of human liver. PNAS. doi.org/10.1073/pnas.1412759111


Stickel, F., Buch, S., Zoller, H., Hultcrantz, R., Gallati, S., Österreicher, C., … Hampe, J. (2014). Evaluation of genome-wide loci of iron metabolism in hereditary hemochromatosis identifies PCSK7 as a host risk factor of liver cirrhosis. Human Molecular Genetics. doi.org/10.1093/hmg/ddu076


 Ahrens, M., Ammerpohl, O., Von Schönfels, W., Kolarova, J., Bens, S., Itzel, T., … Hampe, J. (2013). DNA methylation analysis in nonalcoholic fatty liver disease suggests distinct disease-specific and remodeling signatures after bariatric surgery. Cell Metabolism. doi.org/10.1016/j.cmet.2013.07.004


Brosch, M., Von Schönfels, W., Ahrens, M., Nothnagel, M., Krawczak, M., Laudes, M., … Hampe, J. (2012). SFRS10 - A splicing factor gene reduced in human obesity? Cell Metabolism. doi.org/10.1016/j.cmet.2012.02.002


Stickel, F., Buch, S., Lau, K., Zu Schwabedissen, H. M., Berg, T., Ridinger, M., … Hampe, J. (2011). Genetic variation in the PNPLA3 gene is associated with alcoholic liver injury in caucasians. Hepatology. doi.org/10.1002/hep.24017


Buch, S., Schafmayer, C., Vlzke, H., Seeger, M., Miquel, J. F., Sookoian, S. C., … Hampe, J. (2010). Loci from a genome-wide analysis of bilirubin levels are associated with gallstone risk and composition. Gastroenterology. doi.org/10.1053/j.gastro.2010.09.003


Buch, S., Schafmayer, C., Völzke, H., Becker, C., Franke, A., Von Eller-Eberstein, H., … Hampe, J. (2007). A genome-wide association scan identifies the hepatic cholesterol transporter ABCG8 as a susceptibility factor for human gallstone disease. Nature Genetics. doi.org/10.1038/ng2101


Hampe, J., Grebe, J., Nikolaus, S., Solberg, C., Croucher, P. J. P., Mascheretti, S., … Schreiber, S. (2002). Association of NOD2 (CARD 15) genotype with clinical course of Crohn’s disease: A cohort study. Lancet. doi.org/10.1016/S0140-6736(02)08590-2