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POSTPONED: Adult hippocampal neurogenesis and neurodegenerative diseases

CMCB Life Sciences Seminar

Datum:26/03/2020, 13:00 - 14:00
Sprecher: María Llorens-Martín, Centre for Molecular Biology "Severo Ochoa", CBMSO. Department of Molecular Neuropathology. Madrid (Spain)
Ort: CRTD, ground floor, auditorium left
Gastgeber: Federico Calegari

 

5 most important publications:

Unraveling human adult hippocampal neurogenesis. Flor-García M; Terreros-Roncal J; Moreno-Jiménez E.P; Ávila J; Rábano A; Llorens-Martín M. Nature Protocols. 2020 Jan 8. doi:  10.1038/s41596-019-0267-y.

Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in Alzheimer´s disease patients. Moreno-Jiménez E.P; Flor-García M; Terreros-Roncal J; Rábano A, Cafini F, Pallas-Bazarra N, Ávila J, Llorens-Martín M. Nature Medicine. 2019 Apr; 25(4): 554-60. PMID: 30911133.

Activity-dependent reconnection of adult-born dentate granule cells in a mouse model of frontotemporal dementia. Terreros-Roncal J; Flor-García M*; Moreno-Jiménez EP*; Pallas-Bazarra N*; Rábano A; Sah N; van Praag H; Giacomini D; Schinder AF; Ávila J; Llorens-Martín M. The Journal of Neuroscience. 2019 Jul 17; 39(29):  5794-5815. PMID: 31133559.

Novel function of Tau in regulating the effects of external stimuli on adult hippocampal neurogenesis. Pallas-Bazarra N, Jurado-Arjona J, Navarrete M, Esteban JA, Hernández F, Ávila J, Llorens-Martín M. The EMBO Journal. 2016 Jul 1; 35 (13): 1417-36. PMID: 27198172.

GSK-3β overexpression causes reversible alterations on postsynaptic densities and dendritic morphology of hippocampal granule neurons in vivo. Llorens-Martín M, Fuster-Matanzo A, Teixeira CM, Jurado-Arjona J, Ulloa F, DeFelipe J, Rábano A, Hernández F, Soriano E, Ávila J. Molecular Psychiatry. 2013 Apr; 18(4): 451-60. PMID:  23399915.

Abstract:

Our research group investigates the mechanisms that control adult hippocampal neurogenesis, both under physiological and pathological conditions. We perform in vivo and in vitro studies animal models of different diseases, and also use human brain samples. In particular, we are interested in determining the therapeutic potential of increasing adult hippocampal neurogenesis for the treatment of neurodegenerative diseases such as Alzheimer´s disease (AD) and other tauopathies, and psychiatric disorders. The hippocampus is one of the most affected areas in these diseases. This brain region plays a crucial role in learning and memory. Furthermore, a unique feature of this structure is the existence of adult neurogenesis. The process of adult hippocampal neurogenesis encompasses the birth and functional integration of newborn neurons throughout lifetime. Adult hippocampal circuit confers and extraordinary degree of plasticity to the circuit. 

Thus, we aim at developing strategies capable of increasing the functionality of newborn neurons.

Everybody is welcome!