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RNA Biology and its link to human diseases

CMCB LifeScience Seminar für Forscher

Datum:28/03/2019, 16:00 - 17:00
Sprecher: Prof. Utz Fischer, University of Würzburg, Biocenter
Ort: CRTD, ground floor, auditorium left
Gastgeber: Prof. Rolf Jessberger (Institute of Physiological Chemistry)

Abstract
The generation of messenger RNAs (mRNAs) and their translation into proteins depends on the elaborate interplay of a numerous trans-acting factors. These factors are often organized in macromolecular machines, which enable all steps in mRNA metabolism and timely coordinate their progression. The Fischer group studies the functional dynamics of key macromolecular machines acting on RNA using a combination of biochemical, structural and systems biology approaches. RNA-related pathways have been linked to a broad spectrum of human diseases. By combining basic RNA research with biomedical approaches we investigate how these pathways and networks are changed in different disease settings.

Papers
Impaired spliceosomal UsnRNP assembly leads to Sm mRNA down-regulation and Sm protein degradation AB Prusty, R Meduri, BK Prusty, J Vanselow, A Schlosser, U Fischer J Cell Biol 216 (8), 2391-2407 (2017)

Reconstitution of the human U snRNP assembly machinery reveals stepwise Sm protein organization Neuenkrichen, N., Englbrecht, C., Ohmer, J., Ziegenhals, T., Chari, A., and Fischer, U. EMBO Journal 34(14):1925-41 (2015)

Deletion of TOP3β, a component of FMRP-containing mRNPs, contributes to neurodevelopmental disorders. Stoll G, et al., Nature Neuroscience 16: 1228-1237 (2013)

Intronic miR-26b controls neuronal differentiation by repressing its host transcript, ctdsp2 Dill H, Linder B, Fehr A, Fischer U Genes & Development 26(1):25-30 (2012)

An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs Chari A, Golas M, Neuenkirchen N, Klingenhäger M, Sander B, Englbrecht C, Sickmann A, Stark H, Fischer U Cell 135:497-509 (2008)