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Technology Transfer

Patents

Patent title

Inventor(s)

Publication No.

Date

Method for producing polarized retinal progenitor cells from pluripotent stem cells and their differentiation into retinal pigment epithelium cells

Elly Tanaka

Yu Zhu

US 9249390 B2

02/02/2016

EP 2383333 B1

25/05/2015

Methods and compositions for reducing interleukin-4 or interleukin-13 signaling

Christian Bökel

Thomas Weidemann

US 8,771,682 B2

08/07/2014

A fluorescence based reporter construct for the direct detection of TGF-beta receptor activation and modulators thereof

Christian Bökel

Thomas Weidemann

EP 2141179 B1

01/12/2010

Methods and compositions for the expansion of somatic stem cells and progenitor cells

Federico Calegari

Benedetta Artegiani

Claudia Waskow

Tatyana Grinenko

EP 2380972 B1

19/09/2012

 

Case Studies

Collaboration between Prof. Federico Calegari and Exiqon A/S (Denmark) for detection of circular RNAs (circRNAs) and their associated molecular complexes using Exiqon's LNA™ oligonucleotide probes.

Newly discovered circular RNAs (circRNAs) may play many important biological functions, particularly in brain development. To capture circRNAs of interest, as well as their associated molecular complexes, and elucidate their functions and molecular mechanisms, Prof. Federico Calegari's group and Exiqon A/S (www.exiqon.com) are cooperating to investigate the use of Exiqon's proprietary oligonucleotide probes (LNA™ technology) for circRNA isolation. Prof. Calegari said, "Current limitations in available research tools and methods for analysing the RNA interactome hinder the understanding of complexity in circRNA functions. Together with Exiqon we will assess the LNA™ technology to overcome these limitations and provide insight into the functions of circRNAs".

Within a BMBF funded project Prof. Marius Ader is collaborating with Miltenyi Biotec for the identification of cell surface markers allowing enrichment of iPS-derived retinal cells for transplantation.

The groups of Prof. Marius Ader and Dr. Mike Karl at the CRTD are developing protocols for the generation of transplantable retinal cells from human induced pluripotent stem cells (hiPS). In a joined effort with Miltenyi Biotec (http://www.miltenyibiotec.com) cell surface markers for the classification and enrichment of specific donor cells for cell-based treatment approaches in retinal degenerative diseases will be identified as an essential step in therapy development for blinding diseases.