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Deconstruction thymus development to reconstruct immunity from human pluripotent stem cells

CMCB Life Sciences Seminar

Date:30/01/2020, 13:00 - 14:00
Speaker: René Maehr, University of Massachusetts Medical School
Location: CRTD, ground floor, auditorium left
Host: Maximina Yun

5 most important publications:

Min SY, Desai A, Yang Z, Sharma A, DeSouza T, Genga RMJ, Kucukural A, Lifshitz LM, Nielsen S, Scheele C, Maehr R, Garber M, Corvera S. Diverse repertoire of human adipocyte subtypes develops from transcriptionally distinct mesenchymal progenitor cells. *Proc Natl Acad Sci U S A*. 2019 Aug 16.

Genga RMJ, Kernfeld EM, Parsi KM, Parsons TJ, Ziller MJ, Maehr R. Single-Cell RNA-Sequencing-Based CRISPRi Screening Resolves Molecular Drivers of Early Human Endoderm Development. *Cell Reports*. 2019 Apr 16; 27(3):708-718.e10.

Fischer DS, Fiedler AK, Kernfeld EM, Genga RMJ, Bastidas-Ponce A, Bakhti M, Lickert H, Hasenauer J, Maehr R. Inferring population dynamics from single-cell RNA-sequencing time series data. *Nat Biotechnol*. 2019 04; 37(4):461-468.

Kernfeld EM, Genga RMJ, Neherin K, Magaletta ME, Xu P, Maehr R. A Single-Cell Transcriptomic Atlas of Thymus Organogenesis Resolves Cell Types and Developmental Maturation.*Immunity*. 2018 Jun 19; 48(6):1258-1270.e6.

Parsi KM, Hennessy E, Kearns N, Maehr R. Using an Inducible CRISPR-dCas9-KRAB Effector System to Dissect Transcriptional Regulation in Human Embryonic Stem Cells. *Methods Mol Biol*. 2017; 1507:221-233.

Everybody is very welcome!