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Minimal systems for microtubule-based polarity

CMCB Life Sciences Seminar

Date:14/05/2020, 15:00 - 16:00
Speaker: Marileen Dogterom, Kavli Insitute of Nanoscience at Delft University of Technology
Location: Zoom Video Conferencing
Host: Stefan Diez

Link to the conference -  Zoom Meeting ID: 978 6190 3519, Password: 04751

Abstract:

In my group we are interested in understanding how dynamic and force-generating properties of the microtubule cytoskeleton contribute to the spatial organisation of cells. 

Over the years, we have worked on the reconstitution of minimal, functional cytoskeletal systems at increasing levels of complexity. 

Examples are the reconstitution, in artificial confinement, of basic mitotic spindles, and the topic of today: the design of minimal systems for the study of microtubule-based polarity. 

These efforts fit in a long-term ambition to build, in collaboration with others, a complete synthetic cell from scratch.    

5 most important publications:

S. Roth, I.C. Gârlea, M. Vleugel, B.M. Mulder, M. DogteromReconstitution of basic mitotic spindles in cell-like confinement (bioRxiv)

L. Laan, N. Pavin, J. Husson, G. Romet-Lemonne, M. van Duijn, M. Preciado-Lopez, R. D.  Vale, F. Jülicher, S. L. Reck-Peterson, and M. Dogterom, Cortical dynein controls microtubule dynamics to generate pulling forces that position microtubule asters, Cell 148, 502-514 (2012).

P. Bieling, L. Laan, H. Schek, L. Munteanu, L. Sandblad, D. Brunner, M. Dogterom, and T. Surrey, Reconstitution of a microtubule plus-end tracking system in vitro, Nature 450, 1100-1105 (2007)   

J.W.J. Kerssemakers, E.L. Munteanu, L. Laan, T.L. Noetzel, M.E. Janson, and M. DogteromAssembly dynamics of microtubules at molecular resolution, Nature 442, 709-712 (2006).

M. Dogterom and B. Yurke, Measurement of the force-velocity relation for growing microtubules, Science 278, 856 (1997) 

Prof. Dr. Dogterom will be happy to have a chat with who is interested after her talk.