2011

In 2011, the CRTD funded ten projects with Seed Grants within the CRTD network.

Prof. Ezio Bonifacio/ Prof. Stefan Diez
Development of highly-sensitive and specific autoantibody assays for monitoring relapse of autoimmunity in beta cell replacement therapies

Dr. Karsten Kretschmer / Prof. Ezio Bonifacio / Dr. Robert Geffers
Mechanisms of CD4+IL-10+Foxp3- T regulatory cell generation in mice and humans

Prof. Dirk Lindemann / Dr. Mike O. Karl
Cell reprogramming to induce retinal multipotent progenitors by eye field transcription factors

Dr. Claudia Waskow / Dr. Federico Calegari
Cell cycle tuning as regulator of haematopoietic stem cell function

Dr. Mike O. Karl / Prof. Gerd Kempermann / Dr. Marius Ader / Prof. Richard Funk
Novel ways to investigate and compare roles of neuronal activity in neurogenesis in health and disease

Prof. Michael Bachmann / Prof. Martin Bornhäuser / Dr. Malte von Bonin / Prof. Ezio Bonifacio
Targeting alloreactive T cells with bispecific anti-CD127 antibodies to prevent/treat acute Graft versus host disease after allogeneic hematopoetic stem cell transplantation

Dr. Gilbert Weidinger / Prof. Elly Tanaka
Osteoblast dedifferentiation during Axolotl bone regeneration and repair

Dr. Monika Ehrhart-Bornstein / Prof. Carsten Werner / Prof. Alexander Storch
Axonal outgrowth of sympathoadrenal progenitor cellderived dopaminergic neurons on heparin-polyethylene glycol gels with controlled mechanical properties

Dr. Andreas Androutsellis-Theotokis / Prof. Michael Brand
Regulating endogenous neural stem cells by peripheral pharmacological means

Dr. Federico Calegari / Prof. Gerd Kempermann
Conditional Expansion of Neural Stem Cells and Neurogenesis in Senescent Mice

2010

In 2010, the CRTD funded twelve projects with Seed Grants within the CRTD network.

Dr. Sophie Pautot / Prof. Rainer Jordan
Fabrication of Monodisperse Microgels from Poly(2-oxazoline)s as Scaffolds for Neuronal Cell Replacement Therapy

Prof. Torsten Tonn/ Prof. Martin Bornhäuser/ Prof. Marc Schmitz / Dr. Konstantinos Anastassiadis/ Prof. Carsten Werner/ Prof. Klaus-Peter Günther/ Prof. Stefan Bornstein
Establishment and qualification of a GMP-compliant mesenchymal stem cell bank (MSCB) as platform for regenerative cellular therapies within the CRTD

Prof. Elly Tanaka / Dr. Andy Oates
Establishment of Zinc Finger Nuclease technology to obtain targeted gene deletion and homologous recombination in Dresden model organisms

Dr. Claudia Waskow / Dr. Denis Corbeil
Dissecting the role of prominin-1 in hematopoietic stem cells

Dr. Mike O. Karl / Prof. Michael Brand
Probing Niches to overcome roadblocks of mammalian regeneration

PD Dr. Stefan Rammelt / Dr. Volker Betz/ Prof. Martin Bornhäuser/ Prof. Hans Zwipp
Regeneration of large bone defects by implantation of gene activated, autologous fat tissue: Evaluation in a sheep model

Dr. Marius Ader / Prof. Elly Tanaka/ Dr. Mike O. Karl
Pluripotent stem cells for the replacement of retinal pigment epithelium in a mouse model of retinal degeneration

Prof. Michael Bachmann / Dr. Karsten Kretschmer
Redirecting of regulatory T cells to transplanted tissue by bispecific recombinant antibodies for induction of tolerance

Dr. Maik Stiehler / Prof. Martin Bornhäuser
Dynamic perfusion bioreactor systems for bone tissue engineering

PD Dr.Stefan Rammelt / Dr. Volker Betz/ Prof. Martin Bornhäuser/ Prof. Hans Zwipp
Facilitated endogenous repair: Development of an expedited, single-surgery approach to cartilage regeneration based upon the use of gene activated, autologous fat tissue

Prof. Triantafyllos Chavakis / Prof. Georg Breier/ Dr. Monika Ehrhart-Bornstein
The role of hypoxia and HIF-2alpha for adipose tissue regeneration in metabolic-vascular disease.

Dr. Andreas Beyer / Prof. Gerd Kempermann
Identifying genetic interactions controlling adult neurogenesis

2009

In 2009, the CRTD funded seven projects within the CRTD network.

Dr. Karen Echeverri  / Cenix (Dr. Birte Sönnichsen) 
Skin repair and regeneration: translating regenerative ability from salamanders to mammals by manipulation of microRNA pathways involved in scarless wound-healing in salamanders

Prof. Lorenz Hofbauer / Dr. Christine Hamann / Prof. Klaus Peter Günther / Dr. Ricardo Bernhardt  
Improving bone regeneration in rats with diabetes mellitus by targeting the Wnt signaling pathway with sclerostin antobodies

Dr. Karsten Kretschmer / Prof. Gerd Kempermann   
Mechanisms of CD4+ T cell-mediated Neuro-Immune Crosstalk in
Adult Hippocampal Neurogenesis

Prof. Alexander Storch / Dr. Matthias Löhle / Dr. Konstantinos Anastassiadis    
Characterization of the neuronal differentiation potential of induced pluripotent stem cells derived from murine neural stem cells after reprogramming with a different number of retrovirally introduced transcription factors

Prof. Ursula Ravens / Prof. Elly Tanaka     
Direct reprogramming of mature cells into cardiomyocytes

Dr. Claudia Waskow / Prof. Martin Bornhäuser   
Analysis of the human cancer stem cell hierarchy in mice

Dr. Gilbert Weidinger / Dr. Federico Calegari    
The role of cell cycle length in regulating progenitor cell fate during bone regeneration

2008

In 2008, the CRTD funded ten projects within the CRTD network.

Dr. Marius Ader  / Dr. Denis Corbeil  
Does the cellular environment influence the survival of damaged photoreceptor cells?

Dr. Christian  Bökel  /  Dr. Thomas Weidemann / Prof. Petra Schwille        
Development of reporter constructs for the live imaging of Jak/Stat signalling

Prof. Michael Brand / Dr. Christopher Antos     
Genetic analysis of mechanisms controlling adult neurogenesis and regeneration in adult zebrafish CNS

Prof. Herwig  Gutzeit / Dr. Gilbert Weidinger / Dr. Christopher Antos    
Biology of cultured gonial stem cells in fish

Prof. Michael Kasper / Prof. Ruth Strasser / Dr. Kathrin Barth    
Functional studies of the P2X7 receptor in heart diseases by biochemical investigations employing the Caveolin-1 knockout/knockdown model

Dr. Kai  Loewenbrück  / Prof. Alexander  Storch
Monitoring the effects of environmental factors on physiologic regulation of adult neurogenesis in humans using 1H-MR spectroscopy

Dr. Barbara Ludwig / Dr. Florian Ehehalt / Prof. Stefan Bornstein    
Extended Quality Control of Pancreatic Islets for Clinical Transplantation

Dr. Sophie Pautot / Prof. Günter Lauer / Prof. Bernard Hoflack     
Colloidal alloys as cell carriers for dental implants: A solution to prevent jaw bone resorption after tooth extraction

Dr. Maik  Stiehler / Prof. Martin Bornhäuser      
Optimization of harvest procedure. Three-dimensional cultivation, and osteogenic stimulation of mesenchymal stem cells for bone regeneration

Dr. Claudia Waskow / Prof. Lorenz C. Hofbauer / Prof. Rolf Jessberger    
Prospective isolation of osteoclast precursors

2007

In 2007, there have been fifteen projects granted in the CRTD network.

 
Dr. Moritz Brandt / Prof. Alexander Storch   
The role of VEGF signaling in adult hippocampal neurogenesis in mice: Induction of cell proliferation and survival in a conditional VEGF-receptor- knockout model

Dr. Monika Ehrhart-Bornstein / Dr. Elly Tanaka
Isolation, Characterization and Long-term Culturing of Adrenal Medullary Chromaffin Progenitor Cells. 

Prof. Katrin Engelmann / Prof. Richard Funk / Dipl-Ing. Monika  Valtink  
Transplantation of immuno-modulated (riboflavin/UVA-treated) corneal transplants in an animal model

Prof. Katrin Engelmann / PD Dr. Dirk Lindemann  
Development of strategies for transient immortalization of primary cells using human corneal endothelial cells (HCEC) as a model system

Dr. Gudrun Goßrau / Dr. Konstantinos Anastassiadis  
ES Cell-derived murine enteric nervous system precursors for cell replacement in SOX10+/- mice, an animal model of Hirschsprung’s disease

Prof. Herwig O. Gutzeit
Spermatogonial Stem cells in Medaka  

Prof. Lorenz C. Hofbauer / Prof. Henning Morawietz
Schützt eine Rank-Ligand-Blockade in einem murinen Modell der Glukokortikoid-Induzierten  Osteoporose
vor  Knochenverlust  und Gefässkalifizierung?
   
Dr. Karsten Kretschmer / Prof. Rolf Jessberger / Prof. Bernard Hoflack  
Protein Expression in Immunosuppression  

Prof. Günter Lauer / Dr. Manolo Hagedorn / Prof. Martin Bornhäuser / Prof. Bernard Hoflack
Approaching mouse non-hematopoietic/ mesenchymal stem cells
   
Prof. Gerhard Rödel / Prof. Martin Bornhäuser   
Biogenesis of the mitchondrial membrane proteome during cellular differentiation   

Prof. Angela Rösen-Wolff / Dr. Michael Gelinsky   
In vitro remodeling of artificial 3D extracellular bone matrix   

Dr. Knut Schäkel  
Programming of regulatory T cells by slanDC (6-sulfoLacNAc expressing dentritic cells)   

Prof. Hans-Joachim Schnittler / Prof. Hans Zwipp / Prof. Francis Stewart / Dr. Federico Calegari  
Functional role of endothelial Eps15 in tissue regeneration   
 
Dr. Attila Tóth / Dr. Konstantinos Anastassiadis / Prof. Rolf Jessberger / Prof. Francis Stewart  
Development of pluripotent spermatogonial stem cell lines for assessment of pluripotency and therapeutic potential.
   
Dr. Gilbert Weidinger / Prof. Carsten Werner 
Functional improvement of zebrafish heart regeneration by delivery of signaling molecules   

2006

In 2006, the CRTD funded nine projects with "Seed grands" within the network of the CRTD:

 
Dr. Andreas Hermann / Prof. Alexander Storch / (Prof. Carsten Werner)
Bridging transplantation for reconstructing the nigrostriatal dopaminergic pathway: Combining orthotopic transplantation of stem cell-derived dopaminergic neurons and collagen matrix-orientated axonal outgrowth

Prof. Klaus-Peter Günther / Prof. Martin Bornhäuser
Evaluation of stem-cell-loaded bone transplants in hip revision surgery. A phase 1/2 clinical trial

Dr. Thomas Illmer / Dr. Markus Schaich
Differential expression of MiRNA duringmyeloid differentiation – lessons learned from malignant hematopoesis
           
Dr. Elly Tanaka / Dr. Matthias Kirsch / Prof. Carsten Werner
Development of a therapeutic strategy for spinal cord injury using stem cells grown in microfabricated polymeric surfaces
       
Dr. Denis Corbeil / Prof. Wieland Huttner
Physiological role of Prominin-2 -Development of a conditional knock-out mouse line        

Prof. Günter Lauer / Dr. Denis Corbeil / Prof. Martin Bornhäuser / Prof. Bernard Hoflack
Establishing optimized techniques for cell tracking in controlled in situ bone regeneration

Dr. Winfried Göttsch / Dr. Sven Seifert / Prof. Henning Morawietz / Prof. Hans-Detlef Saeger
Transcriptionsfaktoren hey2 und COUP-TFII als Determinanten der arteriovenösen Differenzierung von Endothelzellen
       
Dr. Sebastian Brenner / Dr. Martin Ryser
Generation of lentiviral siRNA Libraries for identification of genes involved in hematopoetic stem cell migration and adherence

Prof. Richard Funk / Dr. Denis Corbeil
Oxidative stress in age-related macular degeneration- causative factors, rescue and regeneration