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Funded Projects

CRTD Seed Grants 2016 / 2017

In 2016/17, the CRTD funds six projects within the CRTD network.

Prof. Axel Roers / Dr. Andreas Dahl
Single cell transcriptome analysis of small cell populations (too small for microfluidics  technology) for identification of factors regulating hematopoietic stem cell numbers

Prof. Ben Wielockx / Prof. Lorenz Hofbauer / Dr. Martina Rauner

The regeneration potential of erythropoietin (Epo) during skin wound and bone fracture healing in mice

Prof. Jochen Hampe / Dr. Andreas Dahl / Dr. Markus Burkhardt
Epigenetic tracking of stem cell faith in murine and human liver

Dr. Michell Reimer / Dr. Michael Wagner
Pharmacological intervention to modulate electrophysiological recovery in demyelination

Prof. Stefan Diez / Prof. Andreas Hermann

The role of molecular motors in motor neuron disease pathophysiology

Dr. Holger Henneicke / Prof. Federico Calegari
The endocrine control of adult neurogenesis by glucocorticoids


CRTD Postdoctoral Seed Grants 2016 / 2017

In 2016, the CRTD funds two projects within the CRTD network.

Christian Cohrs / Ioannis Giannios / Daniela Pezzolla

Longitudinal assessment of the in vivo matuaration of human ES cell-derived beta-like cells in the anterior chamber of the eye

Anne Eugster / Sumeet Pal Singh

Dissecting Functional Heterogeneity in beta-cells using Single-cell RNA Seq

 

Gerok Positions 2016 / 2017

In 2016, the CRTD funds two projects within the CRTD network.

PD Andreas Hermann / Prof. Min Ae Lee-Kirsch / Dr. K. F. Loewenbrück

The role of innate inflammatory response as possible link of neurodegeneration and nucleic acid metabolism

Prof. Richard H. W. Funk / Dr. Mike Karl /  Prof. Marius Ader / Prof. Katrin Engelmann / Dr. Dierk Wittig

Investigation of human retina donor tissue of patients with retinal diseases to facilitate development of stem cell-derived human retina model systems and regenerative therapies.

 

CRTD Seed Grants 2016 / 2017

In 2016, the CRTD funds four projects within the CRTD network.

Prof. Martin Bornhäuser / Dr. Marc Schmitz
Early prediction of clinical response in patients with steroid-refractory acute graft-versus-host disease during treatment with third-party mesenchymal stromal cells

Prof. Min Ae Lee-Kirsch / Dr. Anne Eugster / Dr. Claudia Günther

Identification of genetic pathways contributing to type 1 interferonopathies

Prof. Andreas Birkenfeld / Prof. Triantafyllos Chavakis

Role of intermediary metabolism and immune responses related to mINDY in liver regeneration after hemihepatectomy in mice

Prof. Marius Ader / Dr. Dirk Sandner / Dr. Mike Karl

Development of a large animal model (pig) for transplantation of human pluripotent stem cell-derived cells into the retina

 

CRTD Seed Grants 2016

In 2016, the CRTD funds three projects within the CRTD network.

Jared Sterneckert, PhD / Prof. Alexander Storch / Dr. Dr. Andreas Herrmann
Assay development and screening for compounds protecting human neurons against ALS pathology

Anthony Gavalas, PhD / Dr. Stephan Speier / Prof. Michele Solimena
Signals and transcription factors in the conversion of human pluripotent stem cells into functional β-cells

Prof. Marius Ader / Dr. Thorsten-Lars Schmidt / Dr. Thomas Kurth
Multiplex 3D CLEM - A new system for parallel visualization of multiple proteins within ultrathin-structurally reconstructed retinal tissue

 

CRTD postdoctoral Seed Grants 2015

In 2015, the CRTD funds for the first time three projects within the CRTD network.

JiFeng Fei (Tanaka) / Sumeet Pal Singh (Ninov)
Inducible Cas9/CRISPR for Conditional Gene Knockouts in Vertebrate Regenerative Model Systems

Cristina Golfieri (Karl) / Seba Almedawar (Tanaka) / Simon Klapper (Busskamp)

Inducing functional photoreceptor outer segments in human retinal organoids by retinal pigment epithelium co-cultures and micro RNA overexpression

Tara Walker (Kempermann) / Sonja Schallenberg (Kretschmer)
Regulation of the physical-activity-induced increase in adult neurogenesis via crosstalk between the adaptive immune system and neural stem cells

 

Gerok Positions 2015 / 2016

In 2015, the CRTD funds two projects within the CRTD network.

Prof. Martin Bornhäuser / Prof. Marc Schmitz / Dr. Thomas Krüger

Functional profiling of the hematopoietic stem cell niche in graft versus host disease mediated bone marrow insufficiency

Prof. Axel Roers / Prof. Martin Aringer / Dr. Martin Achleitner

Role of DNA damage responses in a novel mouse model of human fibrotic disease and clinical implications of these findings

 

CRTD Seed Grants 2015

In 2015, the CRTD funds eight projects within the CRTD network.

Prof. Dirk Lindemann / Prof. Frank Buchholz / Dr. Federico Calegari
In Vitro and In Vivo Genome Editing by Viral Vector-Mediated Transient CRISPRCas9 Expression

Dr. Joerg Mansfeld / Nikolay Ninov, PhD

A human-zebrafish platform for high-throughput identification of pathways controlling β-cell proliferation

Dr. Sebastian Brenner / Prof. Michael Bachmann
Immune response modulation by target-specific manipulation of plasmacytoid dendritic cells

Prof. Alexander Storch / Dr. Andreas Hermann / Jared Sterneckert, PhD

MeDSALS: Mechanisms of disease spreading and axonal transport defects in iPSCderived motor neurons from patients carrying ALS related mutations

Prof. Martin Bornhäuser / Dr. Malte von Bonin / Prof. Jochen Hampe
Epigenetic reprogramming for efficient ex-vivo expansion of hematopoietic stem cells

Prof. Ezio Bonifacio / Dr. Andreas Dahl / Dr. Anne Eugster

miRNA-Sequencing for Biomarkers discovery from small clinical samples

Prof. Lorenz Hofbauer / Prof. Michael Brand / Dr. Martina Rauner / Dr. Franziska Knopf
Zebrafish as a model to unravel the mechanisms of glucocorticoid-induced bone loss

Dr. Ben Wielockx / Prof. Axel Roers / Dr. Tatyana Grinenko
Fate decisions in early hematopoietic progenitors during stress

 

Gerok Positions 2014 / 2015

In 2014, the CRTD funds three projects within the CRTD network.

Prof. Ezio Bonifacio / Prof. Johannes Schetelig / Dr. Cornelia Link

Analysis of the T-cell receptor reservoir in lymphocyte subpopulations after allogeneic stem cell transplantation

Prof. Lorenz Hofbauer / Prof. Martin Bornhäuser / Maria Winzer
Interactions of interleukin-6 and the Wnt inhibitor Dickkopf-1 in inflammation-induced bone loss

Prof. Gerd Kempermann / Prof. Alexander Storch / Dr. Moritz Brandt / Daniel Sippel

The electrophysiological link between adult neurogenesis in the hippocampus and sleep dependent memory consolidation

 

CRTD Seed Grants 2014

In 2014, the CRTD funds six projects within the CRTD network.

Prof. Ezio Bonifacio / Prof. Karsten Kretschmer

Establishing a model of IL-7 driven graft failure

Prof. Michael Brand / Prof. Triantafyllos Chavakis

Role of inflammatory cytokine signals in adult vertebrate brain regeneration

Dr. Ben Wielockx / Prof. Lorenz Hofbauer / Dr. Martina Rauner
Concurrent effects of erythropoietin on the bone and HSC niche  

Prof. Jochen Guck / Dr. Manja Wobus
Evaluation of mechanical properties as a novel tool to characterize human hematopoietic stem cells 

Anthony Gavalas, PhD / Dr. Barbara Ludwig
Functional analysis and molecular profiling of a rare adult pancreas subpopulation with stem cell features  

Prof. Axel Roers / Prof. Frank Buchholz

Establishment of a large-scale RNAi in vivo screen to identify genes controlling DNA damage response, cell cycle and survival of RNase H2-deficient B cells

 

Gerok Positions 2013

In 2013, the CRTD funds three projects within the CRTD network.

Prof. Elly Tanaka / Prof. Matthias Kirsch / Robert Later
Label-free nonlinear optical imaging as a tool for studying spinal cord regeneration after injury in vivo

Prof. Christian Hugo / Prof. Carsten Werner / Esther Rosenkranz

Renal subcapsular implantation of growth factor functionalized starPEG-heparin hydrogels to stimulate kidney regeneration

Prof. Ezio Bonifacio / PD Dr. Johannes Schetelig / Dr. Cornelia Link

Analysis of the T-cell receptor repertoire in lymphocyte subpopulations after allogeneic stem cell transplantation

 

Translational Grant 2013

In 2013, the CRTD funds for the first time one project with a Translational RAC Grant within the CRTD network

Prof. Angela Hübner / Dr. Katrin Köhler

The triple A syndrome as a neurodegenerative disease – the potential of antioxidative treatment

 

CRTD Seed Grants 2013

In 2011, the CRTD funds five projects within the CRTD network.

Christopher Antos, PhD / Prof. Richard Funk
Determining the in vivo relationships between changes in intracellular ion distribution and the proliferation and patterning of progenitor cells in the zebrafish blastema

Prof. Martin Bornhäuser / Dr. Nona Shayegi / Dr. Malte von Bonin
Chemical screen for regulators of hematopoietic stem and progenitor cell activity

Prof. Frank Buchholz / Dr. Martin Wermke
A cancer-stem-cell specific shRNA-screen to identify novel targets for the treatment of acute myeloid leukemia

Dr. Mike Karl / Prof. Triantafyllos Chavakis / Prof. Edmund Koch / Dr. Matina Economopoulou / Prof. Richard Funk

Vascular regeneration in the retina

Dr. Claudia Waskow / Prof. Martin Bornhäuser

Establishing a mouse model for human erythropoiesis

 

CRTD Seed Grants 2012

In 2012, the CRTD funds ten projects within the CRTD network.

Prof. Martin Bornhäuser / Prof. Ezio Bonifacio / Dr. Karsten Kretschmer
Fab-multimer-based purification of autologous and allogeneic regulatory T-cells for stem cell transplantation and autoimmune disease

Prof. Lorenz C. Hofbauer  / Dr. Christine Hamann / Dr. Barbara Ludwig / Prof. Martin Bornhäuser
Concurrent effects of parathyroid hormone on bone regeneration and islet cell protection in diabetic rats

Dr. Konstantinos Anastassiadis  / PD Dr. Dirk Lindemann / Dr. Sebastian Brenner

Development of methods for integration-free reprogramming to iPS-cells

Dr. Denis Corbeil  / Prof. Wieland Huttner / Prof. Michael Bachmann
New insight into the prostate that lacks endegenous prominin-1 (CD133) and/or prominin-2 proteins

Prof. Marino Zerial  / Prof. Carsten Werner

Development of embryonic organ culture to study liver regeneration

Prof. Günter Lauer / Prof. Gustavo B. Baretton / Dr. Volker Betz / PD Dr. Stefan Rammelt / Prof. Hans Zwipp

Gene-activated autologous fat transplants for bone regeneration: Moving forward towards a clinical trial evaluating the effectiveness and safety using a clinical grade adenoviral BMP-2 vector in a large animal model

Prof. Edmund Koch / Dr. Marius Ader / Dr. Mike Karl
In vivo visualization of retinal degenerative processes and intraretinal cell tracking using noninvasive optical imaging techniques

Dr. Michael Gelinsky / Prof. Klaus-Peter Günther

Design of complex scaffolds for tissue interfaces by 3D multi-channel plotting

Dr. Marius Ader  / Dr. Karsten Kretschmer

Immune Modulation to enhance long-term maintenance of transplanted photoreceptors

PD Dr. Stefan Rammelt  / Dr. Claudia Rentsch / Dr. Sebastian Rehberg

Embroidered and surface modified scaffolds as bioartificial bone substitutes in load bearing and unloaded bone defects - An animal pilot-study in sheep

 

CRTD Seed Grants 2011

In 2011, the CRTD funds ten projects within the CRTD network.

Prof. Ezio Bonifacio/ Prof. Stefan Diez

Development of highly-sensitive and specific autoantibody assays for monitoring relapse of autoimmunity in beta cell replacement therapies

Dr. Karsten Kretschmer / Prof. Ezio Bonifacio / Dr. Robert Geffers

Mechanisms of CD4+IL-10+Foxp3- T regulatory cell generation in mice and humans

Prof. Dirk Lindemann / Dr. Mike O. Karl

Cell reprogramming to induce retinal multipotent progenitors by eye field transcription factors

Dr. Claudia Waskow / Dr. Federico Calegari

Cell cycle tuning as regulator of haematopoietic stem cell function

Dr. Mike O. Karl / Prof. Gerd Kempermann / Dr. Marius Ader / Prof. Richard Funk
Novel ways to investigate and compare roles of neuronal activity in neurogenesis in health and disease

Prof. Michael Bachmann / Prof. Martin Bornhäuser / Dr. Malte von Bonin / Prof. Ezio Bonifacio

Targeting alloreactive T cells with bispecific anti-CD127 antibodies to prevent/treat acute Graft versus host disease after allogeneic hematopoetic stem cell transplantation

Dr. Gilbert Weidinger / Prof. Elly Tanaka
Osteoblast dedifferentiation during Axolotl bone regeneration and repair

Dr. Monika Ehrhart-Bornstein / Prof. Carsten Werner / Prof. Alexander Storch
Axonal outgrowth of sympathoadrenal progenitor cellderived dopaminergic neurons on heparin-polyethylene glycol gels with controlled mechanical properties

Dr. Andreas Androutsellis-Theotokis / Prof. Michael Brand
Regulating endogenous neural stem cells by peripheral pharmacological means

Dr. Federico Calegari / Prof. Gerd Kempermann
Conditional Expansion of Neural Stem Cells and Neurogenesis in Senescent Mice

 

CRTD Seed Grants 2010

In 2010, the CRTD funds twelve projects within the CRTD networkt.

Dr. Sophie Pautot / Prof. Rainer Jordan
Fabrication of Monodisperse Microgels from Poly(2-oxazoline)s as Scaffolds for Neuronal Cell Replacement Therapy

Prof. Torsten Tonn/ Prof. Martin Bornhäuser/ Prof. Marc Schmitz / Dr. Konstantinos Anastassiadis / Prof. Carsten Werner/ Prof. Klaus-Peter Günther/ Prof. Stefan Bornstein

Establishment and qualification of a GMP-compliant mesenchymal stem cell bank (MSCB) as platform for regenerative cellular therapies within the CRTD

Prof. Elly Tanaka / Dr. Andy Oates

Establishment of Zinc Finger Nuclease technology to obtain targeted gene deletion and homologous recombination in Dresden model organisms

Dr. Claudia Waskow / Dr. Denis Corbeil
Dissecting the role of prominin-1 in hematopoietic stem cells

Dr. Mike O. Karl / Prof. Michael Brand

Probing Niches to overcome roadblocks of mammalian regeneration

PD Dr. Stefan Rammelt / Dr. Volker Betz/ Prof. Martin Bornhäuser/ Prof. Hans Zwipp
Regeneration of large bone defects by implantation of gene activated, autologous fat tissue: Evaluation in a sheep model

Dr. Marius Ader / Prof. Elly Tanaka/ Dr. Mike O. Karl

Pluripotent stem cells for the replacement of retinal pigment epithelium in a mouse model of retinal degeneration

Prof. Michael Bachmann / Dr. Karsten Kretschmer

Redirecting of regulatory T cells to transplanted tissue by bispecific recombinant antibodies for induction of tolerance

Dr. Maik Stiehler / Prof. Martin Bornhäuser

Dynamic perfusion bioreactor systems for bone tissue engineering

PD Dr.Stefan Rammelt / Dr. Volker Betz/ Prof. Martin Bornhäuser/ Prof. Hans Zwipp

Facilitated endogenous repair: Development of an expedited, single-surgery approach to cartilage regeneration based upon the use of gene activated, autologous fat tissue

Prof. Triantafyllos Chavakis / Prof. Georg Breier/ Dr. Monika Ehrhart-Bornstein

The role of hypoxia and HIF-2alpha for adipose tissue regeneration in metabolic-vascular disease.

Dr. Andreas Beyer / Prof. Gerd Kempermann

Identifying genetic interactions controlling adult neurogenesis

 

CRTD Seed Grants 2009

In 2009, the CRTD funds seven projects within the CRTD networkt.

Dr. Karen Echeverri  / Cenix (Dr. Birte Sönnichsen)

Skin repair and regeneration: translating regenerative ability from salamanders to mammals by manipulation of microRNA pathways involved in scarless wound-healing in salamanders

Prof. Lorenz Hofbauer / Dr. Christine Hamann / Prof. Klaus Peter Günther / Dr. Ricardo Bernhardt 

Improving bone regeneration in rats with diabetes mellitus by targeting the Wnt signaling pathway with sclerostin antobodies

Dr. Karsten Kretschmer / Prof. Gerd Kempermann  
Mechanisms of CD4+ T cell-mediated Neuro-Immune Crosstalk in
Adult Hippocampal Neurogenesis

Prof. Alexander Storch / Dr. Matthias Löhle / Dr. Konstantinos Anastassiadis  
 
Characterization of the neuronal differentiation potential of induced pluripotent stem cells derived from murine neural stem cells after reprogramming with a different number of retrovirally introduced transcription factors

Prof. Ursula Ravens / Prof. Elly Tanaka    
Direct reprogramming of mature cells into cardiomyocytes

Dr. Claudia Waskow / Prof. Martin Bornhäuser  
Analysis of the human cancer stem cell hierarchy in mice

Dr. Gilbert Weidinger / Dr. Federico Calegari   

The role of cell cycle length in regulating progenitor cell fate during bone regeneration

 

CRTD Seed Grants 2008

In 2008, the CRTD funds ten projects within the CRTD network.

Dr. Marius Ader  / Dr. Denis Corbeil 

Does the cellular environment influence the survival of damaged photoreceptor cells?

Dr. Christian  Bökel  /  Dr. Thomas Weidemann / Prof. Petra Schwille       
Development of reporter constructs for the live imaging of Jak/Stat signalling

Prof. Michael Brand / Dr. Christopher Antos    
Genetic analysis of mechanisms controlling adult neurogenesis and regeneration in adult zebrafish CNS

Prof. Herwig  Gutzeit / Dr. Gilbert Weidinger / Dr. Christopher Antos
   
Biology of cultured gonial stem cells in fish

Prof. Michael Kasper / Prof. Ruth Strasser / Dr. Kathrin Barth
   
Functional studies of the P2X7 receptor in heart diseases by biochemical investigations employing the Caveolin-1 knockout/knockdown model

Dr. Kai  Loewenbrück  / Prof. Alexander  Storch

Monitoring the effects of environmental factors on physiologic regulation of adult neurogenesis in humans using 1H-MR spectroscopy

Dr. Barbara Ludwig / Dr. Florian Ehehalt / Prof. Stefan Bornstein 
  
Extended Quality Control of Pancreatic Islets for Clinical Transplantation

Dr. Sophie Pautot / Prof. Günter Lauer / Prof. Bernard Hoflack    
Colloidal alloys as cell carriers for dental implants: A solution to prevent jaw bone resorption after tooth extraction

Dr. Maik  Stiehler / Prof. Martin Bornhäuser  
   
Optimization of harvest procedure. Three-dimensional cultivation, and osteogenic stimulation of mesenchymal stem cells for bone regeneration

Dr. Claudia Waskow / Prof. Lorenz C. Hofbauer / Prof. Rolf Jessberger   
Prospective isolation of osteoclast precursors

 

CRTD Seed Grants 2007

In 2007, there have been fifteen projects granted in the CRTD network.

Dr. Moritz Brandt / Prof. Alexander Storch  
The role of VEGF signaling in adult hippocampal neurogenesis in mice: Induction of cell proliferation and survival in a conditional VEGF-receptor- knockout model

Dr. Monika Ehrhart-Bornstein / Dr. Elly Tanaka
Isolation, Characterization and Long-term Culturing of Adrenal Medullary Chromaffin Progenitor Cells.

Prof. Katrin Engelmann / Prof. Richard Funk / Dipl-Ing. Monika  Valtink 
Transplantation of immuno-modulated (riboflavin/UVA-treated) corneal transplants in an animal model

Prof. Katrin Engelmann / PD Dr. Dirk Lindemann 
Development of strategies for transient immortalization of primary cells using human corneal endothelial cells (HCEC) as a model system

Dr. Gudrun Goßrau / Dr. Konstantinos Anastassiadis 
ES Cell-derived murine enteric nervous system precursors for cell replacement in SOX10+/- mice, an animal model of Hirschsprung’s disease

Prof. Herwig O. Gutzeit
Spermatogonial Stem cells in Medaka 

Prof. Lorenz C. Hofbauer / Prof. Henning Morawietz
Schützt eine Rank-Ligand-Blockade in einem murinen Modell der Glukokortikoid-Induzierten  Osteoporose vor Knochenverlust und Gefässkalifizierung?
  
Dr. Karsten Kretschmer / Prof. Rolf Jessberger / Prof. Bernard Hoflack 
Protein Expression in Immunosuppression 

Prof. Günter Lauer / Dr. Manolo Hagedorn / Prof. Martin Bornhäuser / Prof. Bernard Hoflack
Approaching mouse non-hematopoietic/ mesenchymal stem cells
  
Prof. Gerhard Rödel / Prof. Martin Bornhäuser  
Biogenesis of the mitchondrial membrane proteome during cellular differentiation  

Prof. Angela Rösen-Wolff / Dr. Michael Gelinsky  
In vitro remodeling of artificial 3D extracellular bone matrix  

Dr. Knut Schäkel 
Programming of regulatory T cells by slanDC (6-sulfoLacNAc expressing dentritic cells)  

Prof. Hans-Joachim Schnittler / Prof. Hans Zwipp / Prof. Francis Stewart / Dr. Federico Calegari 
Functional role of endothelial Eps15 in tissue regeneration  
 
Dr. Attila Tóth / Dr. Konstantinos Anastassiadis / Prof. Rolf Jessberger / Prof. Francis Stewart 
Development of pluripotent spermatogonial stem cell lines for assessment of pluripotency and therapeutic potential.
  
Dr. Gilbert Weidinger / Prof. Carsten Werner
Functional improvement of zebrafish heart regeneration by delivery of signaling molecules

 

CRTD Seed Grants 2006

In 2006, the CRTD funds nine projects with "Seed grands" within the network of the CRTD:

Dr. Andreas Hermann / Prof. Alexander Storch / (Prof. Carsten Werner)
Bridging transplantation for reconstructing the nigrostriatal dopaminergic pathway: Combining orthotopic transplantation of stem cell-derived dopaminergic neurons and collagen matrix-orientated axonal outgrowth

Prof. Klaus-Peter Günther / Prof. Martin Bornhäuser
Evaluation of stem-cell-loaded bone transplants in hip revision surgery. A phase 1/2 clinical trial

Dr. Thomas Illmer / Dr. Markus Schaich
Differential expression of MiRNA duringmyeloid differentiation – lessons learned from malignant hematopoesis
          
Dr. Elly Tanaka / Dr. Matthias Kirsch / Prof. Carsten Werner
Development of a therapeutic strategy for spinal cord injury using stem cells grown in microfabricated polymeric surfaces
      
Dr. Denis Corbeil / Prof. Wieland Huttner
Physiological role of Prominin-2 -Development of a conditional knock-out mouse line       

Prof. Günter Lauer / Dr. Denis Corbeil / Prof. Martin Bornhäuser / Prof. Bernard Hoflack
Establishing optimized techniques for cell tracking in controlled in situ bone regeneration

Dr. Winfried Göttsch / Dr. Sven Seifert / Prof. Henning Morawietz / Prof. Hans-Detlef Saeger
Transcriptionsfaktoren hey2 und COUP-TFII als Determinanten der arteriovenösen Differenzierung von Endothelzellen
      
Dr. Sebastian Brenner / Dr. Martin Ryser
Generation of lentiviral siRNA Libraries for identification of genes involved in hematopoetic stem cell migration and adherence

Prof. Richard Funk / Dr. Denis Corbeil
Oxidative stress in age-related macular degeneration- causative factors, rescue and regeneration