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Bone and Tissue Regeneration

The focus of the research area Bone and Tissue Regeneration is to define the molecular and cellular mechanisms of bone regeneration as well as the interactions of immune and cancer cells within bone regeneration. Elucidated key factors are tested in preclinical animal models that represent established human bone diseases as well as in early clinical studies.

To accomplish the overall goal and to guide the translational process, we pursue three specific strategies:

  1. A basic research approach using animal models that have the ability to self-regenerate, including the zebrafish and the axolotl. The intention of this approach is to identify novel targets together with its molecular mechanisms for intervention. This will provide the basis for the development of targeted and better-defined therapeutic strategies for bone/cartilage loss and injury.
  2. A systemic targeted approach using defined molecules of bone remodeling as therapeutic targets. These targets include RANK ligand and sclerostin, two regulators of osteoclast and osteoblast biology, respectively. Antibodies against RANKL named denosumab have been evaluated and after approval have been used for the treatment of osteoporosis and skeletal metastases. Moreover, antibodies against sclerostin have been evaluated in a bone defect model in diabetic rats and showed superior effects compared to the osteo-anabolic hormone PTH. Current phase II/III studies are ongoing using these promising anti-sclerostin antibodies (romosozumab) in humans with bone diseases.
  3. Expanding clinical therapy by focusing on three topics:
  • Use of GMP-grade adult human mesenchymal stem cells (MSC) from bone marrow and cancellous bone for musculoskeletal tissue regeneration.
  • Understanding of osteocyte biology, as these cells and their products (sclerostin, FGF-23) are increasingly recognized to play a central regulatory role of bone and mineral homeostasis.
  • Development of functional biomaterials and the generation of bone-like structures in bioreactors.

CRTD Core Research Groups

Olaf Bergmann: Dynamics and Mechanisms of Cell Renewal
Olaf Bergmann: Dynamics and Mechanisms of Cell Renewal

We are interested in studying mechanisms and turnover dynamics of cell renewal in various organ systems....

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Endocrine Control of Skeletal & Metabolic Regeneration - Holger Henneicke
Endocrine Control of Skeletal & Metabolic Regeneration - Holger Henneicke

We are interested in the endocrine control of degeneration and regeneration during the ageing process...

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Animal Models of Regeneration: Elly Tanaka
Animal Models of Regeneration: Elly Tanaka

Our group seeks to understand the cellular mechanisms underlying salamander limb and spinal cord regeneration as a...

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CRTD Member Groups

NameResearch field
Dr. Christopher AntosAppendage and Organ Regeneration in Zebrafish
Prof. Dr. Michael GelinskyBone tissue engineering
Prof. Dr. Klaus-Peter GüntherBone tissue engineering
Prof. Dr. Lorenz HofbauerEndocrinology / metabolic bone diseases
Prof. Dr. med. dent. Günter LauerBone tissue engineering
PD Dr. med. Michael MudersEndocytosis, autophagy, neuropilins, mouse pathology, surgical pathology
Prof. Dr. Stefan RammeltBone
Jochen Rink, PhDScale and proportion during planarian regeneration
Prof. Dr. Angela Rösen-WolffPediatrics
Prof. Dr. Günter VollmerMolecular cell physiology and endocrinology / osteoporosis