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Diabetes

The beta-cells of the pancreatic islets are the unique source of insulin, the main hormone for control of blood glucose and its use as an energy source in the body. A reduction in functional beta cell mass, either due to autoimmunity or prolonged insulin resistance, is a common denominator of different forms of diabetes mellitus.

Hence, a main goal of the CRTD is to protect and replace pancreatic islets in order to prevent and cure diabetes. The research is organized under the themes:

  1. Immune therapy
  2. Transplantation
  3. Expansion of beta cell numbers and function
  4. Disease pathophysiology

The Diabetes program has a number of synergistic components and extensions that work together to address these areas. Within Dresden, it includes the CRTD core and its members, the TU Dresden Faculty of Medicine, and the German Center for Diabetes Research/Paul Langerhans Institut (DZD/PLID).

Research Groups

Stem cells in pancreas regeneration: Anthony Gavalas
Stem cells in pancreas regeneration: Anthony Gavalas

We are interested in understanding how extracellular signals and...

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Regenerative Therapies for Diabetes: Ezio Bonifacio
Regenerative Therapies for Diabetes: Ezio Bonifacio

Type I diabetes is characterized by insulin deficiency primarily caused by the autoimmune-mediated destruction of...

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Molecular and Cellular Immunology/Immune Regulation: Karsten Kretschmer
Molecular and Cellular Immunology/Immune Regulation: Karsten Kretschmer

CD4+Foxp3+ regulatory T (Treg) cells play an essential role in maintaining immune...

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Endocrine Control of Skeletal & Metabolic Regeneration - Holger Henneicke
Endocrine Control of Skeletal & Metabolic Regeneration - Holger Henneicke

We are interested in the endocrine control of degeneration and regeneration during the ageing process...

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β-cell biology and regeneration: Nikolay Ninov
β-cell biology and regeneration: Nikolay Ninov

The pancreatic β-cells are the key metabolic sensors and effectors for insulin release, which is the only hormone...

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CRTD Member Groups

NameResearch field
Prof. Dr. med. Stefan BeissertImmunotolerance / cancer stem cells
Prof. Dr. Andreas BirkenfeldInsulin resistance and clinical studies on type 2 diabetes
Prof. Dr. Stefan BornsteinDiabetology
Prof. Dr. Triantafyllos ChavakisVascular Inflammation, Angiogenesis, Diabetes and Kidney
Prof. Dr. med. Jochen HampeGastroenterology and hepatology
Dr. med. Barbara LudwigEndocrinology, metabolism, human and experimental islet transplantation
Prof. Dr. Michele SolimenaCell Biology of Pancreatic Beta Cells