Deutsch
TU Dresden

search

Neurodegenerative Diseases

The research focus of “Neurodegenerative Diseases” is to discover mechanisms controlling neural stem cell proliferation and differentiation and apply this basic knowledge toward preventing neural degeneration. This includes disorders in the brain such as Parkinson’s disease and Amyotrophic Lateral Sclerosis, spinal cord injuries and retinal degeneration.

Neurogenesis in the context of development, adult homeostasis, and after injury has become a particular focus area, including all major regenerative and non-regenerative model organisms, including drosophila, zebrafish, axolotl, mouse and human.
Furthermore the induced pluripotent stem cell (iPSC) technology had been adopted to generate cell models of neurodegenerative diseases, set up drug screens for neurodegenerative diseases and to use iPSC-based transplants for cell replacement strategies in Parkinson’s disease models. A strong community focusing on the retina, spanning basic research up to preclinical cell transplantation models has been established. Molecular pathways and cell assays as potential drug targets have been defined. Furthermore, improved stem cell sources and cell enrichment strategies were identified to improve cell engraftment into the retina.
The CRTD Neurodegeneration research area combines the expertise of CRTD core members together with members of the TU Dresden Faculty of Medicine, the TU Dresden Faculty of Sciences, the Max-Bergmann-Center for Biomaterials of the TU Dresden, the Max-Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG), and the German Center for Neurodegenerative Diseases (DZNE) Dresden.

CRTD Core Research Groups

Development and Regeneration of the Vertebrate Brain: Michael Brand
Development and Regeneration of the Vertebrate Brain: Michael Brand

A fundamental problem in neurobiology is how the multitude of different cells of the brain is generated from their...

more
Cell Replacement in the Mammalian Retina: Marius Ader
Cell Replacement in the Mammalian Retina: Marius Ader

Retinal degeneration due to loss of photoreceptors represents one of the prime causes for disability in industrialized...

more
Proliferation and Differentiation of Neural Stem Cells: Federico Calegari
Proliferation and Differentiation of Neural Stem Cells: Federico Calegari

Essentially all cells of the central nervous system are generated during embryonic...

more
Neuronal cell types and circuit engineering: Volker Busskamp
Neuronal cell types and circuit engineering: Volker Busskamp

In order to understand how parts of the human brain, especially the retina, function in health and disease...

more
Retinal Development and Regeneration: Mike O. Karl
Retinal Development and Regeneration: Mike O. Karl

Our overall goals are to decipher and manipulate mechanisms that control the fate of retinal cells throughout their...

more
Mechanisms of Induced Plasticity of the Brain: Caghan Kizil
Mechanisms of Induced Plasticity of the Brain: Caghan Kizil

Our goal is to learn from zebrafish how to enable the adult brain to better cope with neurodegenerative disease and...

more
Genomics of Regeneration: Gerd Kempermann
Genomics of Regeneration: Gerd Kempermann

We study the interactions of genes and behavioral activity in the regulation of adult hippocampal neurogenesis. Given...

more
iPS Cells and Neurodegenerative Disease: Jared Sterneckert
iPS Cells and Neurodegenerative Disease: Jared Sterneckert

Induced pluripotent stem cell (iPSC) technology offers a unique opportunity to...

more
Regulation of developmental and regenerative processes in the spinal cord: Michell Reimer
Regulation of developmental and regenerative processes in the spinal cord: Michell Reimer

My research interest is to understand mechanisms of developmental...

more
Animal Models of Regeneration: Elly Tanaka
Animal Models of Regeneration: Elly Tanaka

Our group seeks to understand the cellular mechanisms underlying salamander limb and spinal cord regeneration as a...

more






























































CRTD Member Groups

NameResearch field
Dr. Andreas Androutsellis-TheotokisStem cell biology in degenerative disease and cancer
Dr. Denis CorbeilHPSC migration and polarisation
Dr. med. Matina Economopoulou Ophthalmology
Prof. Dr. Richard FunkDegeneration of the retina
Prof. Dr. Jochen GuckCellular Machines
Dr. Dr. Andreas HermannDisease modeling of neurodegenerative diseases using hIPSCs
Prof. Dr. Wieland HuttnerCell biological basis of mammalian neurogenesis
PD Dr. med. Matthias KirschModels of spinal cord injury / Biophotonics
Prof. Dr. Elisabeth KnustCell polarity and retinal degeneration in Drosophila
Prof. Dr. med. Min Ae Lee -KirschMolecular genetics of autoimmune diseases
Prof. Dr. Heinz ReichmannNeuroprotection, etiology and treatment of Parkinson's disease, mitochondrial cytopathies, abnormalities of the mitochondrial genome
Prof. Dr. Gerhard RödelMitochondriopathies, mitochondria in stem cell biology
Prof. Dr. emer. Kai SimonsPancreatic and vascular development