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Endocrine Control of Skeletal & Metabolic Regeneration - Holger Henneicke

We are interested in the endocrine control of degeneration and regeneration during the ageing process. Understanding the hormonal regulation of these processes opens up avenues for therapeutic intervention.

Previous and current research

In the past we have investigated the connection between glucocorticoids and age-related disorders such as osteoporosis and type-2 diabetes. Glucocorticoids are stress hormones produced by the adrenal gland affecting most cells and tissues in the body. At high concentrations glucocorticoids have powerful immunosuppressive properties. Therefore, they are commonly used in clinical medicine, for instance to treat autoimmune disorders. more

Future projects and goals

  • Identification of paracrine or endocrine crosstalk between thermogenic adipose tissue and the skeleton.
  • Examine the role of local glucocorticoid signalling during ageing and age-related diseases.
  • Identify and characterise novel neuroendocrine regulators of skeletal & metabolic homeostasis.
  • Glucocorticoids and the sympathetic nervous system as regulators of skeletal degeneration & regeneration.

Selected publications

Kinross KM, Montgomery KG, Mangiafico SP, Hare LM, Kleinschmidt M, Bywater MJ, Poulton IJ, Vrahnas C, Henneicke H, Malaterre J, Waring PM, Cullinane C, Sims NA, McArthur GA, Andrikopoulos S, Phillips WA Ubiquitous expression of the Pik3caH1047R mutation promotes hypoglycemia, hypoinsulinemia, and organomegaly. FASEB J. 2015;29:1426-34

Henneicke H, Gasparini SJ, Brennan-Speranza TC, Zhou H, Seibel MJ Glucocorticoids and bone: local effects and systemic implications. Trends Endocrinol Metab. 2014; 25:197-211

Brennan-Speranza TC*, Henneicke H*, Gasparini SJ, Blankenstein KI, Heinevetter U, Cogger VC, Svistounov D, Zhang Y, Cooney GJ, Buttgereit F, Dunstan CR, Gundberg C, Zhou H, Seibel MJ Osteoblasts mediate the adverse effects of glucocorticoids on fuel metabolism. J Clin Invest. 2012; 122:4172-89 * equal contribution

Henneicke H, Herrmann M, Kalak R, Brennan-Speranza TC, Heinevetter U, Bertollo N, Day RE, Huscher D, Buttgereit F, Dunstan CR, Seibel MJ, Zhou H Corticosterone selectively targets endo-cortical surfaces by an osteoblast-dependent mechanism. Bone. 2011; 49:733– 742

Herrmann M*, Henneicke H*, Street J, Modzelewski J, Kalak R, Buttgereit F, Dunstan CR, Zhou H, Seibel MJ The challenge of continuous exogenous glucocorticoid administration in mice. Steroids. 2009; 74:245-249 * equal contribution

Group members

Contact

Group Leader

Holger Henneicke, MD PhD
holger.henneicke[at]crt-dresden.de