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Genomic Gastroenterology – Jochen Hampe

The research interest in our group is to unravel the molecular pathways that are implicated in the development of gastrointestinal and hepatological disorders. Specifically, our research focuses on systematic, genome-wide approaches in patient material derived from individuals with disorders such as nonalcoholic liver disease, alcoholic liver disease, gallstone disease, inflammatory bowel disease (IBD), diverticulitis and diverticulosis, colorectal cancer, gallbladder and hepatocellular cancer.

 

 

Figure: Pikrosirius staining of Collagen Type I and III showing diet induced fibrosis in mouse liver

Previous and current research

GENOME-WIDE ASSOCIATION STUDIES

Studies of genetic risk factors of complex disorders, and specifically, genome-wide association studies (GWAS) have been widely employed in the study of complex disorders. Through close cooperation with German and international hospitals and research centers we have actively recruited large cohorts with complex disorders and use these for the identification of novel susceptibility genes for gallstone disease, alcoholic liver cirrhosis, colonic diverticular disease (diverticulosis, diverticulitis), colorectal cancer, hemochromatosis, inflammatory bowel disease and sarcoidosis.

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Future projects and goals

  • To provide a better understanding of liver tissue organization and its impact on the metabolic function in healthy and diseased individuals
  • To delineate the genetic basis of GI tract diseases such as non alcoholic fatty liver disease and diverticulitis
  • To study the role of risk genes in the development of severe liver diseases like steatohepatitis and cirrhosis

Group leader

Selected publications

 

Thangapandi VR, Knittelfelder O, Brosch M, Patsenker E, Vvedenskaya O, .. Hampe* J, Subramanian P*. (2020). Loss of Hepatic Mboat7 Leads to Liver Fibrosis. Gut. https://doi.org/10.1136/gutjnl-2020-320853

Segovia-Miranda, F., Morales-Navarrete, H., Kücken, M., Moser, V., Seifert, S., Repnik, U., … Hampe, J*, Zerial, M*. (2019). Three dimensional spatially resolved geometrical and functional models of human liver tissue reveal new aspects of NAFLD progression. Nature Medicine, 25(12), 1885–1893. doi.org/10.1038/s41591-019-0660-7

Schafmayer, C., Harrison, J. W., Buch, S., Lange, C., Reichert, M. C., Hofer, P., … Hampe, J. (2019). Genome-wide association analysis of diverticular disease points towards neuromuscular, connective tissue and epithelial pathomechanisms. Gut. doi.org/10.1136/gutjnl-2018-317619

Strnad, P., Buch, S., Hamesch, K., Fischer, J., Rosendahl, J., Schmelz, R., …, Hampe, J*, Trautwein, C*. (2019). Heterozygous carriage of the alpha1-antitrypsin PiZ variant increases the risk to develop liver cirrhosis. Gut. doi.org/10.1136/gutjnl-2018-316228

Brosch, M., Kattler, K., Herrmann, A., von Schönfels, W., Nordström, K., Seehofer, D., … Hampe, J. (2018). Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control. Nature Communications, 9(1), 1–11. doi.org/10.1038/s41467-018-06611-5

Stickel, F., Buch, S., Nischalke, H. D., Weiss, K. H., Gotthardt, D., Fischer, J., … Hampe, J. (2018). Genetic variants in PNPLA3 and TM6SF2 predispose to the development of hepatocellular carcinoma in individuals with alcohol-related cirrhosis. The American Journal of Gastroenterology. doi.org/10.1038/s41395-018-0041-8

 

 

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Group members

Contact

 

Group Leader

Prof. Dr. Jochen Hampe

Jochen.Hampe[at]uniklinikum-dresden.de

 Lab Head

Dr. Mario Brosch

mario.brosch[at]tu-dresden.de

Phone: +49 (0)351 458 4683

Lab Activities

Jobs:

M.Sc projects are available from November 2020

Contact: Dr. Mario Brosch

Funding