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Genomic Gastroenterology – Jochen Hampe

The research interest in our group is to unravel the molecular pathways that are implicated in the development of gastrointestinal and hepatological disorders. Specifically, our research focuses on systematic, genome-wide approaches in patient material derived from individuals with disorders such as nonalcoholic liver disease, alcoholic liver disease, gallstone disease, inflammatory bowel disease (IBD), diverticulitis and diverticulosis, colorectal cancer, gallbladder and hepatocellular cancer.

 

 

Figure: Pikrosirius staining of Collagen Type I and III showing diet induced fibrosis in mouse liver

Previous and current research

GENOME-WIDE ASSOCIATION STUDIES

Studies of genetic risk factors of complex disorders, and specifically, genome-wide association studies (GWAS) have been widely employed in the study of complex disorders. Through close cooperation with German and international hospitals and research centers we have actively recruited large cohorts with complex disorders and use these for the identification of novel susceptibility genes for gallstone disease, alcoholic liver cirrhosis, colonic diverticular disease (diverticulosis, diverticulitis), colorectal cancer, hemochromatosis, inflammatory bowel disease and sarcoidosis.

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Future projects and goals

  • To provide a better understanding of liver tissue organization and its impact on the metabolic function in healthy and diseased individuals
  • To delineate the genetic basis of GI tract diseases such as non alcoholic fatty liver disease and diverticulitis
  • To study the role of risc genes in the development of severe liver diseases like steatohepatitis and cirrhosis

Group leader

Selected publications

Buch, S., Stickel, F., Trepo, E., Way, M., Herrmann, A., Nischalke, H.D., … , Schmelz, R., Bruckner, S., Zeissig, S., Stephan, A. M., … ., Franke, A., Zopf, S., Hellerbrand, C., Moreno, C., Franchimont, D., Morgan, M.Y., and Hampe, J. (2015). A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis. Nat Genet 47, 1443-1448.

Horvath, S., Erhart, W., Brosch, M., Ammerpohl, O., von Schonfels, W., Ahrens, M., Heits, N., Bell, J.T., Tsai, P.C., Spector, T.D., Deloukas, P., Siebert, R., Sipos, B., Becker, T., Rocken, C., Schafmayer, C., and Hampe, J. (2014). Obesity accelerates epigenetic aging of human liver. Proc Natl Acad Sci U S A 111, 15538-15543.

Ahrens, M., Ammerpohl, O., von Schonfels, W., Kolarova, J., Bens, S., Itzel, T., Teufel, A., Herrmann, A., Brosch, M., Hinrichsen, H., Erhart, W., Egberts, J., Sipos, B., Schreiber, S., Hasler, R., Stickel, F., Becker, T., Krawczak, Rocken, C., Siebert, R., Schafmayer, C., and Hampe, J. (2013). DNA methylation analysis in nonalcoholic fatty liver disease suggests distinct disease-specific and remodeling signatures after bariatric surgery. Cell Metab 18, 296-302.

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Group members

Contact

Group Leader

Prof. Dr. Jochen Hampe
jochen.hampe[at]uniklinikum-dresden.de

Assistant to Group Leader

Franziska Jantsch
franziska.jantsch[at]uniklinikum-dresden.de
Phone: +49 (0)351 458 5643

Lab Activities

Jobs:

MSc projects are available for 2018

 

Funding