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Mucosal Immunology – Sebastian Zeißig

We are interested in the immunological mechanisms underlying inflammation and inflammation-associated tumorigenesis in the intestine and the liver, with a particular focus on translational research in inflammatory bowel disease and basic research aiming towards a better understanding of the role of lipids in immunity.

Previous and current research

Lipid antigens in immunity
Chronic inflammation and tissue destruction are the basis for inflammatory bowel diseases (IBD) and autoimmune as well as viral hepatitis. These diseases are not only associated with debilitating clinical symptoms but are also key risk factors for the development of inflammation-associated malignancy. The development of novel therapeutic strategies that target these diseases is dependent on a detailed understanding of the cellular and molecular mechanisms underlying chronic inflammation. more

Future projects and goals

The aims of our ongoing and future research are

  • To provide a better understanding of the immunological mechanisms involved in control of homeostasis at mucosal surface
  • To delineate the genetic and immunological basis of chronic inflammatory diseases such as IBD and autoimmune hepatitis
  • To study the role of lipids at the intersection of metabolism, immunity, and cancer

Selected publications

Olszak T, Neves JF, Dowds CM, Baker K, Glickman J, Davidson NO, Lin CS, Jobin C, Brand S, Sotlar K, Wada K, Katayama K, Nakajima A, Mizuguchi H, Kawasaki K, Nagata K, Müller W, Snapper SB, Schreiber S, Kaser A, Zeissig S*, Blumberg RS*.  Protective mucosal immunity mediated by epithelial CD1d and IL-10. Nature. 2014 May 22;509(7501):497-502.   *co-senior authors

Zeissig Y, Petersen, BS, Milutinovic S, Bosse E, Mayr G, Peuker K, Keller A, Kohl M, Laass M, Billmann-Born S, Brandau H, Feller AC, Röcken C, Schrappe M, Rosenstiel P, Reed JC, Schreiber S, Franke A, Zeissig S. XIAP variants associated with NOD1/2 dysfunction in pediatric-onset Crohn’s disease. Gut 2015 Jan;64(1):66-76.

Zeissig S, Blumberg RS. Life at the beginning: perturbation of the microbiota by antibiotics in early life and its role in health and disease. Nat. Immunol. 2014 Mar 19; 15(4): 307-10.

An D, Oh SF, Olszak T, Neves JF, Erturk-Hasdemir D, Lu X, Zeissig S, Blumberg RS, Kasper DL. Sphingolipids from a symbiotic microbe regulate homeostasis of host intestinal natural killer T cells. Cell. 2014 Jan 16;156(1-2): 123-33.

Zeissig S, Murata M, Sweet L, Publicover J, Hu Z, Kaser A, Bosse E, Iqbal J, Hussain MM, Balschun K, Röcken C, Arlt A, Günther R, Hampe J, Schreiber S, Baron JL, Moody DB, Liang JT, Blumberg RS. Hepatitis B virus-induced alterations in hepatocyte CD1d lipid antigens activate natural killer T cells and contribute to protective immunity. Nat. Med. 2012. Jul;18(7):1060-8.

Contact

Group Leader

Prof. Dr. Sebastian Zeißig
sebastian.zeissig[at]crt-dresden.de


Assistant to Group Leader

Klaudia Szostak
klaudia.szostak1[at]tu-dresden.de
Phone: +49 (0)351 458 82305

Lab Activities

Jobs:
MSc projects are available for 2015

News:
(to be updated)