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1. Exploring the molecular cues driving zebrafish central nervous system regeneration

Zebrafish, in striking contrast to mammals, can functionally regenerate complex body structures, including significant portions of the central nervous system. Thus, understanding this regenerative capacity of zebrafish nervous system is of great therapeutic significance to treat neural diseases in humans. We are investigating the genes and the signaling pathways involved in the regeneration of the adult zebrafish central nervous system focusing on the role of neurogenic progenitor cells by using different injury, transcriptional profiling and misexpression methods.

Scientists involved: Sibel Aktay, Avinash Chekuru, Dilce Gozuyasli, Dr. Caghan Kizil, Nikos Kyritsis, Jan Martin Pidun, Weronika Welnicz

Related publications:
Kizil C, Brand M (2011) Cerebroventricular Microinjection (CVMI) into Adult Zebrafish Brain Is an Efficient Misexpression Method for Forebrain Ventricular Cells. PLoS ONE 6(11): e27395. doi:10.1371/journal.pone.0027395.

Kroehne V, Freudenreich D, Hans S, Kaslin J, Brand M. (2011) Regeneration of the adult zebrafish brain from neurogenic radial glia-type progenitors. Development. 138(22):4831-41.
Antos CL, Brand M (2011) Regeneration of Organs and Appendages in Zebrafish: A Window into Underlying Control Mechanisms. In: Encyclopedia of Life Sciences, John Wiley & Sons, Ltd: Chichester www.els.net

Kizil C, Kaslin J, Kroehne V, Brand M (2011). Adult neurogenesis and brain regeneration in zebrafish. Dev Neurobiol. 72(3):429-461.

Kizil C, Dudczig S, Kyritsis N, Machate A, Blaesche J, Kroehne V, Brand M. (2012) The chemokine receptor cxcr5 regulates the regenerative neurogenesis response in the adult zebrafish brain. Neural Dev. 7:27.

Kizil C, Kyritsis N, Dudczig S, Kroehne V, Freudenreich D, Kaslin J, Brand M. (2012) Regenerative neurogenesis from neural progenitor cells requires injury-induced expression of Gata3. Dev Cell. 23(6):1230-7.

Kyritsis N, Kizil C, Zocher S, Kroehne V, Kaslin J, Freudenreich D, Iltzsche A, Brand M. (2012) Acute inflammation initiates the regenerative response in the adult zebrafish brain. Science. 338(6112):1353-6.

Kaslin J, Kroehne V, Benato F, Argenton F, Brand M. (2013) Development and specification of cerebellar stem and progenitor cells in zebrafish: from embryo to adult. Neural Dev. 8(1):9.
Kizil, C., Iltzsche, A., Kaslin, J., Brand, M. (2013) Micromanipulation of Gene Expression in the Adult Zebrafish Brain Using Cerebroventricular Microinjection of Morpholino Oligonucleotides. J. Vis. Exp., (75), e50415.

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