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2. Characterization of neurogenic stem cell niches in zebrafish adult brain

Adult neurogenesis is a conserved trait of all vertebrates studied. It has been investigated in detail in rodents, but very little is known about the composition of neurogenic niches and the cellular nature of progenitors in non-mammalian vertebrates. To understand the cellular characteristics of the progenitor domains, we are investigating the molecular regulatory networks of the neurogenic progenitor cells in different regions of the adult zebrafish brain.

Scientists involved: Vanessa Carlos, Avinash Chekuru, Dr. Heiner Grandel, Dr. Stefan Hans, Dr. Caghan Kizil, Nikos Kyritsis

Related publications:

Grandel, H., Kaslin, J., Ganz, J., Wenzel, I., and Brand, M. (2006). Neural stem cells and neurogenesis in the adult zebrafish brain: origin, proliferation dynamics, migration and cell fate. Developmental Biology, 295(1):263-277.

Kaslin J, Ganz J, Brand M. (2008). Proliferation, neurogenesis and regeneration in the non-mammalian vertebrate brain. Philos Trans R Soc Lond B Biol Sci. 29;363 (1489):101-122.

Kaslin, J., Ganz, J., Geffarth, M., Grandel, H., Hans, S. and Brand M. (2009). Stem Cells in the Adult Zebrafish Cerebellum: Initiation and Maintenance of a Novel Stem Cell Niche. J Neuroscience, 29(19):6142-53.

Ganz J., Kaslin J., Hochmann S., Freudenreich D., Brand M. (2010) Heterogeneity and Fgf dependence of adult neural progenitors in the zebrafish telencephalon. Glia, 58(11):1345-1363

Ganz J, Kaslin J, Freudenreich D, Machate A, Geffarth M, Brand M. (2011) Subdivisions of the adult zebrafish subpallium by molecular marker analysis. J Comp Neurol. 520(3):633-55

Grandel H, Brand M. Comparative aspects of adult neural stem cell activity in vertebrates. Dev Genes Evol. 2013 Mar;223(1-2):131-47

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