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3. Characterization of a novel zebrafish model for Parkinson’s disease

Neurodegenerative diseases such as Alzheimer’s or Parkinson’s are a major public health concern. Despite decades of research, success in reproducing human neurodegeneration in animal models such as mice has been incomplete rasing the need for novel and complementary approaches. Given the twofold advantage of: 1) being a vertebrate; and 2) being a relatively simple organism where to study comprehensive pathology in vivo, in recent years the zebrafish has turned out a promising model to understand human diseases, including motor disorders and neuropsychiatric diseases. We have generated and are currently characterizing a zebrafish mutant with features reminiscent of human Parkinson’s disease (PD). Our aim is to formulate novel hypotheses for PD aetiopathology and/or possible clinical applications.

Scientists involved: Dr. Stefan Hans, Stefano Suzzi

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