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4. Regeneration of the adult zebrafish retina

Since photoreceptor cell loss during adulthood is one of the major causes for blindness in humans, it is of huge interest to investigate retinopathy studies in regenerating model organisms. Unlike mammals, zebrafish gain a tremendous ability to regenerate the retina. We analyze the importance of Fgf signaling in the developing and adult retina. We were able to show that Fgf signaling is required for photoreceptor maintenance. Using different lesion paradigms and the Cre/LoxP technology we are interested in lineage tracing of various cell populations in the regenerating retina and elucidating the underlying mechanisms.

Scientists involved: Karina Geurtzen, Dr. Veronika Kuscha, Anke Weber

Related publications:
Picker, A. and Brand, M. (2005): Fgf-signals from a novel signaling center determine axial patterning of the prospective neural retina. Development 132 (22):4951-4962

Picker A, Cavodeassi F, Machate A, Bernauer S, Hans S, Abe G, Kawakami K, Wilson SW, Brand M. (2009) Dynamic coupling of pattern formation and morphogenesis in the developing vertebrate retina. PLoS Biol. Epub 2009 Oct 13.

Hochmann S, Kaslin J, Hans S, Weber A, Machate A, Geffarth M, Funk R. H. W., Brand M. (2012) Fgf Signaling is Required for Photoreceptor Maintenance in the Adult Zebrafish Retina. PLoS ONE 7(1): e30365.

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