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6. Patterning and the cell movements of the embryonic midbrain-hindbrain boundary in zebrafish

Boundary formation is essential for restricting the intermingling of cells with different developmental potentials, and it also allows formation of local signaling centers. It is the key fundamental process that coordinates growth and patterning of the embryo. Understanding the formation and maintenance of boundaries during growth and morphogenesis is essential for broadening our knowledge on basic developmental biology. We are investigating the molecular mechanisms that regulate boundary formation using various zebrafish mutants.

Scientists involved: Dr. Gokul Kesevan

Related publications:
Langenberg, T.L. and Brand, M. (2005). Lineage restriction maintains a stable organizer cell population at the zebrafish midbrain-hindbrain boundary. Development, 132(14):3209-3216.

Rhinn, M., Lun, K., Luz, M., Werner, M., Brand, M. (2005). Positioning of the midbrain-hindbrain boundary organizer through global posteriorisation of the neuroectoderm mediated by Wnt8 signaling. Development 132, 1261-1272.

Rhinn, M., Picker, A., and Brand, M. (2006). Global and local mechanisms of forebrain and midbrain patterning. Curr Opin Neurobiology 16, 1-8.

Dahmann, C, Oates, AC, Brand, M (2011) Boundary formation and maintenance in tissue development. Nature Review Genetics, 12(1):43-55.

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