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Biofunctional polymer materials – Carsten Werner

Embryonic kidney of the mouse cultivated in a new developed organ culture system (© IPF)

We aim to recapitulate fundamental functions of living matter -such as recognition, assembly, and adaptation- in synthetic, polymer-based materials. Our research priorities are

  • matrix engineering: (cell-instructive materials for tissue and disease models and regenerative therapies),
  • hemocompatibility: (exploring blood-material interactions and developing anti-coagulant, anti-inflammatory and anti-septic coatings) and
  • charging and structure formation at bio-interfaces: tools and methods targeting ionic charge, transport, supramolecular structure and bioadhesion.

 

Fig.: Embryonic kidney of the mouse cultivated in a new developed organ culture system (© IPF)

 

Previous and current research

Glycosaminoglycan-based cell-instructive hydrogels

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Adaptive hemocompatible coatings

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Biomimetic control of wetting and adhesion

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Future projects and goals

The aims of our ongoing and future research are

  • bioinspired approaches to adaptively minimize bacterial adhesion
  • immunomodulatory polymer materials to support wound healing
  • multiphasic morphogenetic polymer matrices for in situ tissue engineering and for organoid cultures

Selected publications

Lohmann, N., Schirmer, L., Atallah, P., Wandel, E., Ferrer, R.A., Werner, C., Simon, J.C., Franz, S., and Freudenberg, U. (2017). Glycosaminoglycan-based hydrogels capture inflammatory chemokines and rescue defective wound healing in mice. Science Translational Medicine 9.

Freudenberg, U., Liang, Y., Kiick, K.L., and Werner, C. (2016). Glycosaminoglycan-Based Biohybrid Hydrogels: A Sweet and Smart Choice for Multifunctional Biomaterials. Advanced Materials 28, 8861-8891.

Hensel, R., Neinhuis, C., and Werner, C. (2016). The springtail cuticle as a blueprint for omniphobic surfaces. Chemical Society Reviews 45, 323-341.

Maitz, M.F., Freudenberg, U., Tsurkan, M.V., Fischer, M., Beyrich, T., and Werner, C. (2013). Bio-responsive polymer hydrogels homeostatically regulate blood coagulation. Nature Communications 4.

Group members

Contact

Group Leader

Prof. Dr. Carsten Werner

Assistant to Group Leader

Jana Renc

Phone: +49 (0)351 4658 531