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Biofunctional polymer materials - Previous and Current Research

Adaptive hemocompatible coatings

We have demonstrated that bio-responsive polymer architectures can empower medical therapies by engaging molecular feedback-response mechanisms resembling the homeostatic adaptation of living tissues to varying environmental constraints: A blood coagulation-responsive hydrogel system was shown to deliver heparin in amounts triggered by the environmental levels of thrombin, the key enzyme of the coagulation cascade, which--in turn- becomes inactivated due to released heparin. The bio-responsive hydrogel quantitatively quenches human blood coagulation over several hours in the presence of pro-coagulant stimuli. Release analogously triggered by the "early" coagulation factors Xa or XIIa enhanced the efficiency of the released anticoagulant, and silver-containing hydrogel layers provided a combination of hemocompatibility and long-term antiseptic capacity.

 

 

 

 

 

 

 

Figure modified from Maitz MF et al. Biomaterials 2017

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