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Hematology/Immunology

A major motivation within the research field Hematology/Immunology is to harness insights obtained in model-system based approaches to develop attractive new adoptive cellular and in-vivo targeted therapies.

The clinical platform for RAC A is hematopoietic stem cell transplantation (HSCT). In addition to clinical studies using engineered HSC grafts, clinical use of mesenchymal stromal cells (MSC) has been advanced for Graft-versus-Host Disease (GvHD), engraftment-failure and tissue engineering approaches. Additional cell therapies with antigen-specific T cells and regulatory T cells (Tregs) have been established in a GMP-grade fashion. Preclinical research in hematology focuses on improving ex vivo culture of HSCs using co-culture systems with MSCs.
In addition to HSC migratory capacity, the regulation of HSC self-renewal and differentiation by intrinsic and microenvironmental cues is a major focus of dedicated research groups. Bioartificial materials are being developed to dissect exogenous signals and mechanisms acting on hematopoietic progenitors and to enable successful long-term culture and expansion for therapeutic use.
The immunology branch of the CRTD mainly focusses on tolerance as a central mechanism of regeneration and how Tregs interact with hematopoiesis and bone regeneration. Novel bispecific antibodies and chimeric-antigen receptor transduced T cells are developed within with the aim of introducing these therapies in the clinic.
New emphasis has been put on the comprehensive modelling of steady-state hematopoiesis and leukemia stem cells using innovative mathematical systems.

CRTD Core Research Groups

Anke Fuchs: Advanced Cellular Therapeutics
Anke Fuchs: Advanced Cellular Therapeutics

Allogeneic hematopoietic stem cell transplantation (HSCT) is a potentially curative treatment for life-threatening hematopoietic disorders such as leukemia and lymphoma.

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Jochen Hampe: Genomic Gastroenterology
Jochen Hampe: Genomic Gastroenterology

The research interest in our group is to unravel the molecular pathways that are implicated in the development of gastrointestinal and hepatological disorders. Specifically...

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Molecular and Cellular Immunology/Immune Regulation: Karsten Kretschmer
Molecular and Cellular Immunology/Immune Regulation: Karsten Kretschmer

CD4+Foxp3+ regulatory T (Treg) cells play an essential role in maintaining immune...

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Michael Sieweke: Stem Cell and Macrophage Biology
Michael Sieweke: Stem Cell and Macrophage Biology

Our research is located at the interface of immunology and stem cell research...

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Maximina Yun: Regeneration of complex structures in adult vertebrates
Maximina Yun: Regeneration of complex structures in adult vertebrates

Humans exhibit rather limited capabilities for tissue repair and regeneration. In contrast, organisms with remarkable regenerative abilities can be found in nature ...

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Mucosal Immunology: Sebastian Zeißig
Mucosal Immunology: Sebastian Zeißig

We are interested in the immunological mechanisms underlying inflammation and inflammation-associated tumorigenesis in...

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CRTD Member Groups

NameResearch field
Prof. Dr. Michael BachmannTumorimmunology and Autoimmunity
Prof. Dr. med. Stefan BeissertImmunotolerance / cancer stem cells
Prof. Dr. Martin BornhäuserHematopoietic cell transplantation
Prof. Dr. Sebastian BrennerHematopoietic stem cell migration
Prof. Dr. Triantafyllos ChavakisVascular Inflammation, Angiogenesis, Diabetes and Kidney
Dr. Denis CorbeilHPSC migration and polarisation
Prof. Dr. Gerhard EhningerHematology / Immunotherapy
Prof. Dr. Rolf JessbergerBiochemistry
Dr. Markus KleinewietfeldCellular and human immunology
Prof. Dr. med. Min Ae Lee -KirschMolecular genetics of autoimmune diseases
Prof. Dr. med. Axel RoersMast cells / Immune regulation
Prof. Dr. med. Mario RüdigerNeonatology / Stem Cells in fetal development
Prof. Dr. Marc SchmitzTumor immunology
Prof. Dr. Torsten TonnCell-based therapies
Prof. Dr. Claudia WaskowRegeneration in Hematopoiesis
Ben Wielockx, PhDThe role of oxygen sensors during physiological and pathological processes in mice