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Mechanisms of Induced Plasticity of the Brain - Previous and current research

A cross section of adult zebrafish brain expressing human version of TAU protein (green). Zebrafish neurons are marked in red.

Our main goals are

  • To identify the molecular mechanisms of neural stem cell plasticity and neurogenic ability in adult zebrafish brain
  • To learn from zebrafish how to enable the adult brains to better cope with neurodegenerative disease and regenerate
  • To translate the findings from zebrafish to mammalian models of Alzheimer's disease in 3D hydrogels and mouse

We are using three distinct but complementary lines of tools and experiments to address the induced plasticity response of fish brain upon neurodegenerative conditions. (1) Generation of “humanized” adult zebrafish models of neurodegenerative pathophysiology, (2) establishment of novel 3D human AD models in chemically-defined hydrogels; (3) in vivo investigation of the findings in zebrafish and 3D cultures by using mouse models of AD.

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