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Genomics of Regeneration - Gerd Kempermann

We study the interaction of genes and behavioral activity in the regulation of adult hippocampal neurogenesis. Given that the hippocampus is critically in many memory processes critical to human life, most notably autobiographic and episodic memory but also including all kinds of declarative learning and spatial orientation, and that the hippocampus is early and prominently affected in dementias and depression, preventing, compensating or reverting loss of hippocampal function is an important target for medicine in an aging society.

Previous and current research

Adult neurogenesis and stem cell biology of the adult brain Against common wisdom even the adult and aging brain can generate new neurons from a population of resident stem cells but it does so only in two privileged regions and on a minute scale. This process, adult neurogenesis, however, is tightly linked to brain function in the hippocampus, a brain area centrally involved in learning and memory processes. This connection makes it likely that adult neurogenesis serves a fundamental function for higher cognitive functions. more

Future projects and goals

Our goal is to understand how new neurons contribute to brain function and health and disease and how lifestyle and activity build a “neurogenic reserve” to allow functional compensation in the face of old age and beginning dementia.

Our specific aims? Stay tuned …

 

 

Selected publications

Garthe A, Roeder I, Kempermann G. Mice in an enriched environment learn more flexibly because of adult hippocampal neurogenesis. Hippocampus. 2015 Aug 27. doi: 10.1002/hipo.22520. [Epub ahead of print] PubMed PMID: 26311488.

Freund J, Brandmaier AM, Lewejohann L, Kirste I, Kritzler M, Krüger A, Sachser N, Lindenberger U, Kempermann G. Association between exploratory activity and
social individuality in genetically identical mice living in the same enriched environment. Neuroscience. 2015 May 15. pii: S0306-4522(15)00459-5. doi: 10.1016/j.neuroscience.2015.05.027. [Epub ahead of print] PubMed PMID: 25987202.

Ehret F, Vogler S, Pojar S, Elliott DA, Bradke F, Steiner B, Kempermann G. Mouse model of CADASIL reveals novel insights into Notch3 function in adult hippocampal neurogenesis. Neurobiol Dis. 2015 Mar;75:131-41. doi: 10.1016/j.nbd.2014.12.018. Epub 2014 Dec 31. PubMed PMID: 25555543.

Freund J, Brandmaier AM, Lewejohann L, Kirste I, Kritzler M, Krüger A, Sachser N, Lindenberger U, Kempermann G. Emergence of individuality in genetically identical mice. Science. 2013 May 10;340(6133):756-9. doi: 10.1126/science.1235294. PubMed PMID: 23661762.

Walker TL, Kempermann G. One mouse, two cultures: isolation and culture of adult neural stem cells from the two neurogenic zones of individual mice. J Vis Exp. 2014 Feb 25;(84):e51225. doi: 10.3791/51225. Erratum in: J Vis Exp. 2014;(93):doi:10.3791/5614. PubMed PMID: 24637893; PubMed Central PMCID: PMC4131911.

Contact

Group Leader

Prof. Dr. Gerd Kempermann
gerd.kempermann[at]crt-dresden.de


Speaker DZNE (German Center for Neurodegenrative Diseases)

Prof. Dr. Gerd Kempermann
gerd.kempermann(at)dzne.de


Assistant to Group Leader

Kristin Baues
kristin.baues[at]crt-dresden.de
Phone: +49 (0)351 458 82200

FUNDING