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Neuronal Cell Types and Circuit Engineering - Volker Busskamp

In order to understand how parts of the human brain, especially the retina, function in health and disease, our research focus is to reverse engineer functional human neuronal circuits from scratch combining neuroscience with stem cell research and bioengineering. Our goal is to generate the basic parts, namely electrically active neurons, from adult human induced stem cells in high yields.

Previous and current research

Previously our focus was to study the human and mouse retina in health and disease. In a blinding disease called Retinitis pigmentosa, the goal was to repair non-functional cone photoreceptors using optogenetics, specifically by expressing microbial Halorhodopsins, to restore visual function in mice. We further translated this approach to post mortem human retinas (Busskamp et al. 2010), which forms the basis for on-going clinical trials. more

Future projects and goals

In order to understand how parts of the human brain function in health and disease, our major aim is to reverse engineer functional human neuronal circuits from scratch combining neuroscience with stem cell research and bioengineering. We plan to generate the basic parts, namely electrically active neurons, from adult human stem cells. Next, we need to understand and control the biology to connect these cells in a reproducible way into defined functional neuronal circuits in vitro. more

Contact

Group Leader

Dr. Volker Busskamp

volker.busskamp[at]tu-dresden.de


Assistant

Eike Lau

Phone: +49 (0)351 458 82354

Telefax: +49 (0)351 458 82059

Email: eike.lau[at]tu-dresden.de

 

 

 

Selected publications

Busskamp V, Lewis NE, Guye P, Ng AHM, Shipman SL, Byrne SE, Murn J, Sanjana NE, Li S, Li Y, Stadler M, Weiss R, Church GM. “Rapid neurogenesis through transcriptional activation in human stem cells”, Molecular Systems Biology 2014 Nov 17;10(11):760

 

Busskamp V, Krol J, Nelidova D, Daum J, Szikra T, Tsuda B, Jüttner J, Farrow K, Gross Scherf B, Patino Alvarez CP, Genoud C, Sothilingam V, Tanimoto N, Stadler M, Seeliger M, Stoffel M, Filipowicz M, Roska. “MicroRNAs 182 and 183 are necessary to maintain adult cone photoreceptor outer segments and visual function”, Neuron 2014 Aug 6;83(3):586-600

 

Busskamp V, Duebel J, Balya D, Fradot M, Viney TJ, Siegert S, Groner AC, Cabuy E, Forster V, Seeliger M, Biel M, Humphries P, Paques M, Mohand-Said S, Trono D, Deisseroth K, Sahel JA, Picaud S, Roska B. ”Genetic Reactivation of Cone Photoreceptors Restores Visual Responses in Retinitis pigmentosa”, Science. 23 July 2010: Vol. 329. no. 5990, pp. 413 – 417.

 

All publications can be found on PubMed and downloaded via ResearchGate.

 

Group members

You can find some of us on ResearchGate:

Volker Busskamp

Anka Kempe (Lab Manager)

Simon Klapper (Postdoc)

Kerstin Lenk (Postdoc)

Evelyn Sauter (PhD student)

Lisa Kutsche (PhD student)

Alex Ng (guest PhD student)

Group leader

Funding

 

Lab activities and News

2017/06/22: Eduardo Rojo will join the lab as a DIGS-BB Springboard-to-Postdoc fellow

2017/06/16: Wir nehmen an der Langen Nacht der Wissenschaften teil. "Was bastelst du aus deiner “Stammzelle"?" - geeignet für Kinder von 18:00 - 22:00 im CRTD.

2017/03/14: Pictures of the Paul Ehrlich und Ludwig Darmstaedter Award ceremony.

2017/03/07: We took part in the "Ideenstudio - Biomicroelectronics" at the TU Dresden.

2017/03/05: Unser Open Access Übersichtsartikel zum Thema "Optogenetik – eine Chance für fortgeschrittene retinale Dystrophien" ist in Klinische Monatsblätter für Augenheilkunde erschienen.

2017/01/23: Volker receives the Paul Ehrlich und Ludwig Darmstaedter Junior Award.

2017/01/05: New publication about the functional maturation of human stem cell-derived neurons is published.

2016/10/22: Volker Busskamp will present at the Retina-Informationstag in Dresden.

2016/10/05: Our preview on optochemical vision restoration is published in Neuron.

2016/08/30: Busskamp lab retreat with our guest speaker/artist Joe Davis to Spreewald.  

2016/08/17: Our first lab paper has been accepted. It is a review article about "Biophysical properties of optogenetic tools and their application for vision restoration approaches". 

 

 

 

Joining the lab

  • All positions are currently filled.

In general, due to the high number of applications for intern, student, PhD and Postdoc positions we are unfortunately unable to answer all requests. If your application has caught our attention, we will get back to you. Future job offers and PhD student positions will be advertised.